PDP anticorps (Middle Region)

N° du produit ABIN954075

Cet anticorps anti-PDP est un anticorps Lapin Polyclonal détectant PDP dans WB, IHC (p) et EIA. Adapté pour Humain.

Aperçu rapide pour PDP anticorps (Middle Region) (ABIN954075)

Antigène: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-PDP anticorps

Épitope: AA 366-395, Middle Region

Specificité: This antibody recognizes Human PDP1 (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogène: KLH conjugated synthetic peptide between 366-395 amino acids from the Central region of Human PDP1

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PDP

Antigène: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Autre désignation: PDP1

Sujet: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported, one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.Synonyms: Mitochondrial [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, PDP, PDPC1, PPM2C, Protein phosphatase 2C, Pyruvate dehydrogenase phosphatase catalytic subunit 1

Poids moléculaire: 61054 Da

ID gène: 54704

NCBI Accession: NP_001155250