PNN anticorps (Middle Region)

N° du produit ABIN954147

Cet anticorps anti-PNN est un anticorps Lapin Polyclonal détectant PNN dans WB, IF, IHC (p) et EIA. Adapté pour Humain.

Aperçu rapide pour PNN anticorps (Middle Region) (ABIN954147)

Antigène: PNN (Pinin, Desmosome Associated Protein (PNN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PNN est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-PNN anticorps

Épitope: AA 216-248, Middle Region

Specificité: This antibody recognizes Human Pinin / PNN (Center).

Purification: Affinitty Chromatography on Protein A

Immunogène: KLH conjugated synthetic peptide between 216-248 amino acids from the Central region of human PNN.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PNN

Antigène: PNN (Pinin, Desmosome Associated Protein (PNN))

Autre désignation: Pinin / PNN

Sujet: Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene, the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.Synonyms: 140 kDa nuclear and cell adhesion-related phosphoprotein, DRS, DRSP, Desmosome-associated protein, Domain-rich serine protein, MEMA, Nuclear protein SDK3

Poids moléculaire: 81614 Da

ID gène: 5411

NCBI Accession: NP_002678