GSAP anticorps (C-Term)

N° du produit ABIN954149

Détail du produit anti-GSAP anticorps

Antigène: GSAP (PION) (Pigeon Homolog (PION))

Épitope: AA 536-565, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GSAP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody recognizes Human PION (C-term).

Purification: Affinity Chromatography on Protein A

Immunogène: KLH conjugated synthetic peptide between 536-565 amino acids from the C-terminal region of human PION

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur GSAP

Antigène: GSAP (PION) (Pigeon Homolog (PION))

Autre désignation: PION / GSAP (PION Produits)

Synonymes: anticorps PION, anticorps A530088I07Rik, anticorps Pion, anticorps gamma-secretase activating protein, anticorps GSAP, anticorps Gsap

Sujet: Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD, MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1, MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP, MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).Synonyms: Gamma-secretase-activating protein, Protein pigeon homolog

Poids moléculaire: 97802 Da

ID gène: 54103

NCBI Accession: NP_059135