Importin 11 anticorps (C-Term)

N° du produit ABIN954448

Cet anticorps Lapin Polyclonal détecte spécifiquement Importin 11 dans WB et EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour Importin 11 anticorps (C-Term) (ABIN954448)

Antigène: Importin 11 (IPO11)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Importin 11 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-Importin 11 anticorps

Épitope: AA 906-970, C-Term

Specificité: This antibody recognizes Human RanBP11 / Importin-11 (C-term).

Purification: Protein A column, followed by peptide affinity purification

Immunogène: KLH conjugated synthetic peptide between 906~970 amino acids from the C-terminal region of Human RanBP11 / Importin-11 Genename: IPO11

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Importin 11

Antigène: Importin 11 (IPO11)

Autre désignation: RanBP11 / Importin-11

Sujet: IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). It mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).Synonyms: IPO11, Imp11, Ran-binding protein 11

Poids moléculaire: 112535 Da

ID gène: 51194

NCBI Accession: NP_001128251

Pathways: Protein targeting to Nucleus