Transferrin Receptor 2 anticorps (C-Term)

N° du produit ABIN955173

Cet anticorps anti-Transferrin Receptor 2 Polyclonal Lapin (ABIN955173) détecte spécifiquement Transferrin Receptor 2 dans WB et EIA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Transferrin Receptor 2 anticorps (C-Term) (ABIN955173)

Antigène: Transferrin Receptor 2 (TFR2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Transferrin Receptor 2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-Transferrin Receptor 2 anticorps

Épitope: AA 673-703, C-Term

Specificité: This antibody detects Human TFR2 (C-term). Other species not tested.

Purification: Protein A column followed by peptide affinity purification

Immunogène: KLH conjugated synthetic peptide between 673-703 amino acids from the C-terminal region of human TFR2

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Détails sur Transferrin Receptor 2

Antigène: Transferrin Receptor 2 (TFR2)

Autre désignation: TFR2

Sujet: This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. Function: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Cellular Location: Cell membrane, Single-pass type II membrane protein. Tissue Location: Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly.Synonyms: Transferrin receptor protein 2

Poids moléculaire: 88755 Da (Calculated)

ID gène: 7036

NCBI Accession: NP_001193784

Pathways: Transition Metal Ion Homeostasis