Uromodulin anticorps (HRP)

N° du produit ABIN955476

Détail du produit anti-Uromodulin anticorps (HRP)

Antigène: Uromodulin (UMOD)

Reactivité: Humain, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Uromodulin est conjugé à/à la HRP

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Enzyme Immunoassay (EIA), Radioimmunoassay (RIA)

Specificité: Anti-Human Tamm-Horsfall protein (THP) is a monoclonal antibody which reacts with an epitope of the urinary mucoprotein. This monoclonal antibody has shown good localization to the distal tubule and collecting duct as well as to large deposits of Tamm-Horsfall protein which has clogged peri-pelvic veins. This antibody has been tested against 21 different Human proteins in Solid Phase Radioimmunoassay and has been shown to be specific for Tamm-Horsfall protein only. Results of ELISA show no visible reaction with Human albumin or transferrin. Also no staining of Human tissue other than that noted for kidney sections has been observed.

Réactivité croisée (Details): Species reactivity (expected):Canine (Dog).
Species reactivity (tested):Human.

Purification: Protein G Chromatography.

Immunogène: Human Tamm-Horsfall protein.

Clone: 01-10-32

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS containing 50 % Glycerol (v/v)., 4-5 mg/mL BSA

Précaution d'utilisation: Avoid exposure of conjugate to Sodium Azide or Thimerosal, as these can inhibit peroxidase activity.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted at (in aliquots) at -20 °C. This product is photosensitive and should be protected from light.

Détails sur Uromodulin

Antigène: Uromodulin (UMOD)

Abstract: UMOD Produits

Synonymes: anticorps ADMCKD2, anticorps FJHN, anticorps HNFJ, anticorps HNFJ1, anticorps MCKD2, anticorps THGP, anticorps THP, anticorps urehr4, anticorps uromodulin, anticorps UMOD, anticorps Umod

Sujet: Tamm-Horsfall Protein (THP) is a glycoprotein of approximately 80 kDa containing up to 25 % carbohydrate by weight. It exists as a high molecular weight polymer in urine and approximately 50 mg of the THP are excreted per day by adult humans. THP is produced by the epithelial cells lining the thick ascending loop of Henle and distal convoluted tubules of the kidney. THP is also the primary constituent of renal tubular casts and THP aggregation has been implicated as a factor in the pathogenesis of acute renal failure by causing tubular obstruction. Antibody to THP is present in the serum of patients with pyelonephritis and reflus uropathy.Synonyms: THP, Tamm-Horsfall urinary glycoprotein

ID gène: 7369

NCBI Accession: NP_001008390

UniProt: P07911