Melanoma Associated Antigen anticorps

N° du produit ABIN959527

Cet anticorps Souris Monoclonal détecte spécifiquement Melanoma Associated Antigen dans IHC, ELISA, IHC (fro), IF, IHC (p) et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour Melanoma Associated Antigen anticorps (ABIN959527)

Antigène: Melanoma Associated Antigen (MAGE)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Melanoma Associated Antigen est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Clone: NKI-C3

Détail du produit anti-Melanoma Associated Antigen anticorps

Specificité: Used for diagnostic by staining of lysosomes/melanosomes. Directed against a predominantly intracellular protein of human melanoma cells. The antigen is abundantly present in malignant melanomas, nevocellular nevi, and neuroendocrine tumors, whereas it has not been detectable in most other tissues. The antigen recognized is a glycoprotein which appears as a broad band in SDS-PAGE. The antigen was shown to consist of a single protein backbone to which two or three V-linked glycans were added cotranslationally. Extensive further heterogeneity was generated in the Colgi compartmen and was shown to be dependent on the presence of complex type sugars. Although the antigen is associated with melanomas, it was not codistributed with the tyrosinase activity associated with melanogenesis. The antigen did show codistribution with cathepsin D, which is a marker for lysosomal functions.This antibody was originally described as a marker for melanoma. Recently, it resurfaced as a marker to separate cellular neurothekeoma from other dermal tumors in the differential diagnosis.

Purification: Purified

Immunogène: Melanoma-associated antigen

Isotype: IgG1

Information d'application

Indications d'application: Approved: ELISA, IF, IHC, IHC-Fr, IHC-P (10 μg/mL), IP

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: avoid freeze thaw cycles. Store undiluted.

Stock: 4 °C,-20 °C

Stockage commentaire: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.

Détails sur Melanoma Associated Antigen

Antigène: Melanoma Associated Antigen (MAGE)

Autre désignation: Melanoma-Associated Antigen