UBASH3B anticorps (C-Term)

N° du produit ABIN964881

N° du produit (Fournisseur): 600-401-870

Cet anticorps anti-UBASH3B est un anticorps Lapin Polyclonal détectant UBASH3B dans IHC, WB, ELISA et FM. Adapté pour Humain et Souris. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour UBASH3B anticorps (C-Term) (ABIN964881)

Antigène: UBASH3B (STS1) (Cbl-Interacting Protein Sts-1 (STS1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBASH3B est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Fluorescence Microscopy (FM)

Détail du produit anti-UBASH3B anticorps

Épitope: C-Term

N° du produit (Fournisseur): 600-401-870

Fournisseur: Rockland

Fonction: Sts-1 Antibody

Réactivité croisée (Details): This affinity purified antibody is directed against mouse Sts-1 protein.

Attributs du produit: Synonyms: rabbit anti-Sts-1 antibody, Sts1, Sts 1, Ubiquitin-associated and SH3 domain-containing protein B, Cbl interacting protein p70 antibody, Suppressor of T-cell receptor signaling 1, T-cell ubiquitin ligand 2, TULA-2, Tyrosine-protein phosphatase STS1/TULA2, Ubash3B

Purification: The product was affinity purified from monospecific antiserum by immunoaffinity purification.

Stérilité: Sterile filtered

Immunogène:

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminus of mouse Sts-1.

Immunogen Type: Conjugated Peptide

Isotype: IgG

Information d'application

Indications d'application:

Immunohistochemistry Dilution: 4 μg/mL

Application Note: This affinity purified antibody has been tested for use in ELISA, IHC, and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band

Western Blot Dilution: 1:500 - 1:3,000

ELISA Dilution: 1:2,000 - 1:10,000

IF Microscopy Dilution: User Optimized

Other: User Optimized

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.63 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Références pour anticorps anti-UBASH3B (ABIN964881)

Carpino, Turner, Mekala, Takahashi, Zang, Geiger, Doherty, Ihle: "Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2." dans: Immunity, Vol. 20, Issue 1, pp. 37-46, (2004) (PubMed).

Carpino, Kobayashi, Zang, Takahashi, Jou, Feng, Nakajima, Ihle: "Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein." dans: Molecular and cellular biology, Vol. 22, Issue 21, pp. 7491-500, (2002) (PubMed).

Détails sur UBASH3B

Antigène: UBASH3B (STS1) (Cbl-Interacting Protein Sts-1 (STS1))

Autre désignation: UBASH3B

Sujet: Background: Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.  Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation.  Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2.   Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens.

ID gène: 84959, 24497612

UniProt: Q8TF42