PNPLA2 anticorps (C-Term)

N° du produit ABIN965617

Cet anticorps Lapin Polyclonal détecte spécifiquement PNPLA2 dans IHC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour PNPLA2 anticorps (C-Term) (ABIN965617)

Antigène: PNPLA2 (Patatin-Like phospholipase Domain Containing 2 (PNPLA2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PNPLA2 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-PNPLA2 anticorps

Épitope: C-Term

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ATGL(adipose triglyceride lipase)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur PNPLA2

Antigène: PNPLA2 (Patatin-Like phospholipase Domain Containing 2 (PNPLA2))

Autre désignation: ATGL (adipose triglyceride lipase)

Sujet: ATGL(adipose triglyceride lipase) may function as a lipase and play a role in the adaptive response to a low energy state, such as fasting, by providing fatty acids to other tissues for oxidation. In addition, decreased expression of desnutrin in obesity models suggests its possible contribution to the pathophysiology of obesity. The adipose triglyceride lipase (ATGL) catalyzes the initial step in triglyceride hydrolysis. ATGL contains a patatin domain common to plant acyl-hydrolases. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals. The iPLA2epsilon (adiponutrin), iPLA2zeta (TTS2.2), and iPLA2eta (GS2) are three novel TAG lipases/acylglycerol transacylases that likely participate in TAG hydrolysis and the acyl-CoA independent transacylation of acylglycerols