Calpain 3 anticorps (C-Term)

N° du produit ABIN965743

Cet anticorps Lapin Polyclonal détecte spécifiquement Calpain 3 dans IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour Calpain 3 anticorps (C-Term) (ABIN965743)

Antigène: Calpain 3 (CAPN3)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Calpain 3 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-Calpain 3 anticorps

Épitope: C-Term

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human CAPN3(Calpain-3)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur Calpain 3

Antigène: Calpain 3 (CAPN3)

Autre désignation: CAPN3

Sujet: CAPN3(Calpain-3) is a calcium-regulated non-lysosomal thiol-protease. It has a broad endopeptidase specificity. CAPN3 is activated by micromolar concentrations of calcium and inhibited by calpastatin. It interacts with TTN/titin. Isoform I is skeletal muscle specific. Defects in CAPN3 are the cause of limb-girdle muscular dystrophy type 2A (LGMD2A). LGMD2A is both autosomal dominantly and recessively transmitted. It is characterized by progressive symmetrical atrophy and weakness of the proximal limb muscles and elevated serum creatine kinase. CAPN3 belongs to the peptidase C2 family and contains 1 calpain catalytic domain and 4 EF-hand domains.

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development