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CELF1 anticorps (N-Term)

CELF1 Reactivité: Humain, Souris, Rat IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN965946
  • Antigène Voir toutes CELF1 Anticorps
    CELF1 (CUGBP, Elav-Like Family Member 1 (CELF1))
    Épitope
    • 14
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 51
    • 22
    • 21
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 39
    • 12
    Lapin
    Clonalité
    • 39
    • 12
    Polyclonal
    Conjugué
    • 27
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp CELF1 est non-conjugé
    Application
    • 36
    • 23
    • 20
    • 8
    • 8
    • 3
    • 3
    • 1
    Immunohistochemistry (IHC)
    Immunogène
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human CUGBP1 (CUG-BP- and ETR-3-like factor 1)
    Top Product
    Discover our top product CELF1 Anticorps primaire
  • Restrictions
    For Research Use only
  • Stock
    4 °C
  • Iakova, Wang, Timchenko, Michalak, Pereira-Smith, Smith, Timchenko: "Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate." dans: The EMBO journal, Vol. 23, Issue 2, pp. 406-17, (2004) (PubMed).

    Paillard, Legagneux, Beverley Osborne: "A functional deadenylation assay identifies human CUG-BP as a deadenylation factor." dans: Biology of the cell / under the auspices of the European Cell Biology Organization, Vol. 95, Issue 2, pp. 107-13, (2003) (PubMed).

    Paillard, Legagneux, Maniey, Osborne: "c-Jun ARE targets mRNA deadenylation by an EDEN-BP (embryo deadenylation element-binding protein)-dependent pathway." dans: The Journal of biological chemistry, Vol. 277, Issue 5, pp. 3232-5, (2002) (PubMed).

    Takahashi, Sasagawa, Usuki, Kino, Kawahara, Sorimachi, Maeda, Suzuki, Ishiura: "Coexpression of the CUG-binding protein reduces DM protein kinase expression in COS cells." dans: Journal of biochemistry, Vol. 130, Issue 5, pp. 581-7, (2001) (PubMed).

    Good, Chen, Warner, Herring: "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator." dans: The Journal of biological chemistry, Vol. 275, Issue 37, pp. 28583-92, (2000) (PubMed).

  • Antigène
    CELF1 (CUGBP, Elav-Like Family Member 1 (CELF1))
    Autre désignation
    CUGBP1 (CELF1 Produits)
    Synonymes
    anticorps CUGBP1, anticorps BRUNOL2, anticorps CUG-BP, anticorps CUGBP, anticorps EDEN-BP, anticorps NAB50, anticorps NAPOR, anticorps hNab50, anticorps 1600010O03Rik, anticorps AA407467, anticorps Brunol2, anticorps CUG-BP1, anticorps Cugbp1, anticorps D2Wsu101e, anticorps HNAB50, anticorps Bruno-like, anticorps brul, anticorps cb920, anticorps cugbp1, anticorps brunol2, anticorps cug-bp, anticorps cug-bp1, anticorps cugbp, anticorps cugbp1-a, anticorps eden-bp, anticorps edenbp, anticorps nab50, anticorps CUGBP Elav-like family member 1, anticorps CUGBP, Elav-like family member 1, anticorps cugbp, Elav-like family member 1, anticorps CUGBP Elav-like family member 1 L homeolog, anticorps CELF1, anticorps Celf1, anticorps celf1, anticorps celf1.L
    Sujet
    CUGBP1 (CUG-BP- and ETR-3-like factor 1) is implicated in the regulation of several post-transcriptional events. CUGBP1 is involved in pre-mRNA alternative splicing, mRNA translation and stability. CUGBP1 mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. CUGBP1 specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. CUGBP1 acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. CUGBP1 activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. CUGBP1 promotes exclusion of exon 11 of the INSR pre-mRNA. CUGBP1 increases translation and controls the choice of translation initiation codon of CEBPB mRNA. CUGBP1 increases mRNA translation of CEBPB in aging liver. CUGBP1 increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. CUGBP1 mediates rapid cytoplasmic mRNA deadenylation. CUGBP1 recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). CUGBP1 binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs).
    Synonyms: BRUNOL2, CELF1, CUGBP, NAB50( CELF-1, Bruno-like protein 2, RNA-binding protein BRUNOL-2, CUG triplet repeat RNA-binding protein 1, Deadenylation factor CUG-BP, 50 kDa nuclear polyadenylated RNA-binding protein, Embryo deadenylation element-binding protein homolog, CUG-BP1, EDEN-BP homolog)
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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