DAXX anticorps

N° du produit ABIN965974

Cet anticorps Souris Monoclonal détecte spécifiquement DAXX dans WB, ELISA, IF et FACS. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour DAXX anticorps (ABIN965974)

Antigène: DAXX (Death-Domain Associated Protein (DAXX))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DAXX est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 7A11

Détail du produit anti-DAXX anticorps

Purification: Antibody are purified by protein G affinity chromatography.

Immunogène: Purified recombinant fragment of human DAXX expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-DAXX (ABIN965974)

Ryu, Chae, Kim: "Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9." dans: Biochemical and biophysical research communications, Vol. 279, Issue 1, pp. 6-10, (2000) (PubMed).

Yang, Khosravi-Far, Chang, Baltimore: "Daxx, a novel Fas-binding protein that activates JNK and apoptosis." dans: Cell, Vol. 89, Issue 7, pp. 1067-76, (1997) (PubMed).

Détails sur DAXX

Antigène: DAXX (Death-Domain Associated Protein (DAXX))

Autre désignation: DAXX

Sujet: DAXX (death-domain associated protein), it is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
Synonyms: DAP6, EAP1, BING2

Poids moléculaire: 81kDa

ID gène: 1616

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway