DISC1 anticorps (C-Term)

N° du produit ABIN965998

Cet anticorps Lapin Polyclonal détecte spécifiquement DISC1 dans IHC. Il présente une réactivité envers Humain et a été mentionné dans 5+ publications.

Aperçu rapide pour DISC1 anticorps (C-Term) (ABIN965998)

Antigène: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DISC1 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-DISC1 anticorps

Épitope: C-Term

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human DISC1(Disrupted in schizophrenia 1 protein)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-DISC1 (ABIN965998)

Taylor, Devon, Millar, Porteous: "Evolutionary constraints on the Disrupted in Schizophrenia locus." dans: Genomics, Vol. 81, Issue 1, pp. 67-77, (2003) (PubMed).

Morris, Kandpal, Ma, Austin: "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation." dans: Human molecular genetics, Vol. 12, Issue 13, pp. 1591-608, (2003) (PubMed).

Ozeki, Tomoda, Kleiderlein, Kamiya, Bord, Fujii, Okawa, Yamada, Hatten, Snyder, Ross, Sawa: "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 1, pp. 289-94, (2003) (PubMed).

Millar, Wilson-Annan, Anderson, Christie, Taylor, Semple, Devon, St Clair, Muir, Blackwood, Porteous: "Disruption of two novel genes by a translocation co-segregating with schizophrenia." dans: Human molecular genetics, Vol. 9, Issue 9, pp. 1415-23, (2000) (PubMed).

Seki, Ohira, Nagase, Ishikawa, Miyajima, Nakajima, Nomura, Ohara: "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain." dans: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 4, Issue 5, pp. 345-9, (1998) (PubMed).

Détails sur DISC1

Antigène: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Autre désignation: DISC1 (Disrupted in schizophrenia 1 protein)

Sujet: DISC1 (Disrupted in schizophrenia 1 protein) is a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. DISC1 is involved in neurite outgrowth and cortical development through its interaction with other proteins. DISC1 interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1. The interaction with microtubules may be mediated in part by TRAF3IP1. A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1,11)(q42.1,q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1.

Pathways: Regulation of Cell Size