DNAJA3 anticorps (C-Term)

N° du produit ABIN966005

Détail du produit anti-DNAJA3 anticorps

Antigène: DNAJA3 (DnaJ (Hsp40) Homolog, Subfamily A, Member 3 (DNAJA3))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNAJA3 est non-conjugé

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of mouse DnaJa3 (DnaJ homolog subfamily A member 3, mitochondrial precursor)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur DNAJA3

Antigène: DNAJA3 (DnaJ (Hsp40) Homolog, Subfamily A, Member 3 (DNAJA3))

Autre désignation: DnaJa3 (DNAJA3 Produits)

Synonymes: anticorps Tid-1, anticorps 1200003J13Rik, anticorps 1810053A11Rik, anticorps C81173, anticorps Tid1l, anticorps HCA57, anticorps TID1, anticorps hTID-1, anticorps DnaJ heat shock protein family (Hsp40) member A3, anticorps Dnaja3, anticorps DNAJA3

Sujet: DnaJa3(DnaJ homolog subfamily A member 3) modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. DnaJa3 affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C, in sharp contrast, isoform 2 suppresses apoptosis. DnaJa3 can modulate IFN-gamma-mediated transcriptional activity. It interacts with JAK2, HSPA9B and IFN-gammaR2 chain. It also interacts with Ras GTPase-activating protein 1 (RASA1). Modulation of apoptosis, i.e proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domaindependent. DnaJa3 contains 1 CR domain and 1 J domain.

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity