GSTP1 anticorps

N° du produit ABIN966240

Cet anticorps anti-GSTP1 est un anticorps Monoclonal détectant GSTP1 dans WB, IHC et ELISA. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour GSTP1 anticorps (ABIN966240)

Antigène: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Reactivité: Humain

Hôte: Veuillez nous consulter SVP

Clonalité: Monoclonal

Conjugué: Cet anticorp GSTP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-GSTP1 anticorps

Specificité: Ni-NTA purified truncated recombinant GSTP1 expressed in E. Coli strain BL21 (DE3)

Purification: Antibodies are purified by protein A affinity chromatography

Isotype: IgG1

Information d'application

Indications d'application: Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
IHC(F): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Stock: -20 °C

Références pour anticorps anti-GSTP1 (ABIN966240)

Lin, Nelson: "Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells." dans: Cancer research, Vol. 63, Issue 2, pp. 498-504, (2003) (PubMed).

Satoh, Itoh, Yamamoto, Tanaka, Hayakari, Ookawa, Yamazaki, Sato, Tsuchida, Hatayama: "Nrf2 transactivator-independent GSTP1-1 expression in "GSTP1-1 positive" single cells inducible in female mouse liver by DEN: a preneoplastic character of possible initiated cells." dans: Carcinogenesis, Vol. 23, Issue 3, pp. 457-62, (2002) (PubMed).

Détails sur GSTP1

Antigène: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Autre désignation: GSTP1

Sujet: GSTP1 (glutathione-S-transferase, pi 1), also called GST3/DFN7, which is located on chromosome 11q13 , is a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. GSTP1 act like a tumor suppressor gene, which when inactivated leads to tumor growth, and the -class glutathione S-transferase is commonly inactivated by somatic CpGisland hypermethylation in cancers of the prostate, liver, and breast. Methylation of regulatory sequences at the GSTP1 gene locus is found in the vast majority (>90%) of prostate carcinomas and is associated with transcriptional down-regulation.

ID gène: 2950

Pathways: Cellular Response to Molecule of Bacterial Origin