Inhibin alpha anticorps

N° du produit ABIN966402

Cet anticorps anti-Inhibin alpha est un anticorps Monoclonal détectant Inhibin alpha dans WB, IHC et ELISA. Adapté pour Humain. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour Inhibin alpha anticorps (ABIN966402)

Antigène: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Reactivité: Humain

Hôte: Veuillez nous consulter SVP

Clonalité: Monoclonal

Conjugué: Cet anticorp Inhibin alpha est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-Inhibin alpha anticorps

Specificité: Ni-NTA purified truncated recombinant INHA expressed in E. Coli strain BL21 (DE3)

Purification: Antibodies are purified by protein A affinity chromatography

Isotype: IgG1

Information d'application

Indications d'application: Western Blot: 1: 500- 1: 1,000
IHC(P): 1: 1,000- 1: 2,000
ELISA: Propose dilution 1: 10,000 Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Stock: -20 °C

Références pour anticorps anti-Inhibin alpha (ABIN966402)

Knight: "Roles of inhibins, activins, and follistatin in the female reproductive system." dans: Frontiers in neuroendocrinology, Vol. 17, Issue 4, pp. 476-509, (1997) (PubMed).

Fahy, Wilson, Beard, Groome, Knight et al.: "Changes in inhibin-A (alpha-beta A dimer) and total alpha inhibin in the peripheral circulation and ovaries of rats after gonadotrophin-induced follicular development and during the normal oestrous ..." dans: The Journal of endocrinology, Vol. 147, Issue 2, pp. 271-83, (1996) (PubMed).

Lambert-Messerlian, Crowley, Schneyer: "Extragonadal alpha-inhibin precursor proteins circulate in human male serum." dans: The Journal of clinical endocrinology and metabolism, Vol. 80, Issue 10, pp. 3043-9, (1995) (PubMed).

Mayo, Cerelli, Spiess, Rivier, Rosenfeld, Evans, Vale: "Inhibin A-subunit cDNAs from porcine ovary and human placenta." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 16, pp. 5849-53, (1986) (PubMed).

Détails sur Inhibin alpha

Antigène: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Autre désignation: INHA

Sujet: INHA(A-inhibin subunit precursor, inhibin alpha subunit ),also called inhibin(alpha) ,which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises of two subunits,Inhibin A and B. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal,bone marrow, placenta, and most notably anterior pituitary. Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.

ID gène: 3623

Pathways: Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion