LCav2b (Isoform B) anticorps

N° du produit ABIN966478

Cet anticorps Lapin Polyclonal détecte spécifiquement LCav2b dans IHC. Il présente une réactivité avec des échantillons de Great Pond Snail (Lymnaea stagnalis). Il a été cité dans 3+ publications.

Aperçu rapide pour LCav2b (Isoform B) anticorps (ABIN966478)

Antigène: LCav2b

Reactivité: Great Pond Snail (Lymnaea stagnalis)

Hôte: Lapin

Clonalité: Polyclonal

Application: Immunohistochemistry (IHC)

Détail du produit

Épitope: Isoform B

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to near N-terminal residues of Great Pond Snail (Lymnaea stagnalis) LCav2b (voltage-dependent non-L-type calcium channel alpha-1 subunit isoform b)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Référence

Spafford, Van Minnen, Larsen, Smit, Syed, Zamponi: "Uncoupling of calcium channel alpha1 and beta subunits in developing neurons." dans: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 41157-67, (2004) (PubMed).

Spafford, Munno, Van Nierop, Feng, Jarvis, Gallin, Smit, Zamponi, Syed: "Calcium channel structural determinants of synaptic transmission between identified invertebrate neurons." dans: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 4258-67, (2003) (PubMed).

Spafford, Chen, Feng, Smit, Zamponi: "Expression and modulation of an invertebrate presynaptic calcium channel alpha1 subunit homolog." dans: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 21178-87, (2003) (PubMed).

Détail du antigène

Antigène: LCav2b

Sujet: LCav2b (voltage-dependent non-L-type calcium channel alpha-1 subunit isoform b) mediates entry of calcium ions into excitable cells. Calcium channel beta subunits are key modulators of calcium channel function and membrane targeting of the pore-forming alpha1 subunit. An invertebrate (Lymnaea stagnalis) homolog of P/Q- and N-type calcium channels (LCav2), although colocalized with beta subunits in synapses of mature neurons, is physically uncoupled from the beta subunits in the leading edge of growth cones of outgrowing neurons. LCav2 channels that mediate transmitter release in mature synapses also participate in neuronal outgrowth in growth cones. The differential association of beta subunits with synaptic calcium channels and those expressed in emergent neuronal growth shows that beta subunits may play a role in the transformation of Cav2 calcium channel function in immature neurons and mature synapses.