Mu Opioid Receptor 1 anticorps (Opioid Receptor, mu 1) (C-Term)

Details for Product anti-OPRM1 Antibody No. ABIN966719, Fournisseur: Connectez-vous pour afficher
Antigène
  • LMOR
  • M-OR-1
  • MOP
  • MOR
  • MOR1
  • OPRM
  • MOP-R
  • MOR-1
  • MOR-1O
  • Oprm
  • mor
  • muOR
  • MORA
  • Oprrm1
  • or2
  • ZFOR2
  • OPRM1
  • opioid receptor mu 1
  • opioid receptor, mu 1
  • outer membrane protein OprM
  • OPRM1
  • Oprm1
  • oprm1
  • oprM1
Épitope
C-Term
29
15
14
10
10
8
8
8
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris
122
73
61
11
8
8
5
3
3
3
2
1
1
1
1
1
1
1
1
1
Hôte
Lapin
124
3
3
Clonalité
Polyclonal
Conjugué
Cet anticorp Mu Opioid Receptor 1 est non-conjugé
5
5
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
93
54
47
33
18
14
10
4
4
2
2
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to very Cterminal residues of human OPRM1(Mu-type opioid receptor)
Plasmids, Primers & others Plasmids, Primers & others Mu Opioid Receptor 1 products on genomics-online (e.g. as negative or positive controls)
Autre désignation OPRM1 (OPRM1 Antibody Extrait)
Sujet OPRM1(Mu-type opioid receptor) inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. OPRM1forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. OPRM1 interacts with RGSZ17 and RGSZ20. OPRM1 is a multi-pass membrane protein. The polymorphism Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form. OPRM1(Mu-type opioid receptor) belongs to the G-protein coupled receptor 1 family.
Pathways cAMP Metabolic Process, Synaptic Membrane
Restrictions For Research Use only
Produit citée dans: Xu, Xu, Hurd, Pasternak, Pan: "Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene." dans: Journal of neurochemistry, Vol. 108, Issue 4, pp. 962-72, 2009 (PubMed).

Pan, Xu, Yu, Xu, Pan, Pasternak: "Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm." dans: Neuroscience, Vol. 133, Issue 1, pp. 209-20, 2005 (PubMed).

Pan, Xu, Mahurter, Xu, Gilbert, Pasternak: "Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X." dans: Biochemical and biophysical research communications, Vol. 301, Issue 4, pp. 1057-61, 2003 (PubMed).

Uhl, Sora, Wang: "The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 14, pp. 7752-5, 1999 (PubMed).

Mestek, Hurley, Bye, Campbell, Chen, Tian, Liu, Schulman, Yu: "The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 3 Pt 2, pp. 2396-406, 1995 (PubMed).

Wang, Johnson, Persico, Hawkins, Griffin, Uhl: "Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment." dans: FEBS letters, Vol. 338, Issue 2, pp. 217-22, 1994 (PubMed).

Bare, Mansson, Yang: "Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain." dans: FEBS letters, Vol. 354, Issue 2, pp. 213-6, 1994 (PubMed).

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