P-Cadherin anticorps (AA 612-626)

N° du produit ABIN966724

Cet anticorps Polyclonal détecte spécifiquement P-Cadherin dans WB, ICC et IHC (p). Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour P-Cadherin anticorps (AA 612-626) (ABIN966724)

Antigène: P-Cadherin (CDH3)

Reactivité: Humain

Hôte: Veuillez nous consulter SVP

Clonalité: Polyclonal

Conjugué: Cet anticorp P-Cadherin est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-P-Cadherin anticorps

Épitope: AA 612-626

Immunogène: A synthetic peptide corresponding to a sequence at the middle region of human P-Cadherin (612-626 aa), different from the mouse and rat sequence by one amino acid.

Information d'application

Indications d'application: WB: The detection limit for P-Cadherin is approximately 2.5ng/lane under non-reducing and reducing conditions.

Restrictions: For Research Use only

Stockage

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Stock: -20 °C

Références pour anticorps anti-P-Cadherin (ABIN966724)

Kaupmann, Becker-Follmann, Scherer, Jockusch, Starzinski-Powitz: "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species." dans: Genomics, Vol. 14, Issue 2, pp. 488-90, (1992) (PubMed).

Détails sur P-Cadherin

Antigène: P-Cadherin (CDH3)

Autre désignation: P-Cadherin

Sujet: Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherin-3 is a protein that in humans is encoded by the CDH3 gene. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.