SYNPO anticorps (AA 495-509)

N° du produit ABIN967124

Détail du produit anti-SYNPO anticorps

Antigène: SYNPO (Synaptopodin (SYNPO))

Épitope: AA 495-509

Reactivité: Humain, Rat

Hôte: Veuillez nous consulter SVP

Clonalité: Polyclonal

Conjugué: Cet anticorp SYNPO est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Immunogène: A synthetic peptide corresponding to a sequence at the middle region of human synaptopodin (495-509 aa), identical to the related mouse and rat sequence.

Information d'application

Restrictions: For Research Use only

Stockage

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Stock: -20 °C

Références pour anticorps anti-SYNPO (ABIN967124)

Cooney, Hurlburt, Selig, Harris, Fiala: "Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 6, pp. 2215-24, (2002) (PubMed).

Deller, Merten, Roth, Mundel, Frotscher: "Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons." dans: The Journal of comparative neurology, Vol. 418, Issue 2, pp. 164-81, (2000) (PubMed).

GRAY: "Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex." dans: Nature, Vol. 183, Issue 4675, pp. 1592-3, (1959) (PubMed).

Détails sur SYNPO

Antigène: SYNPO (Synaptopodin (SYNPO))

Autre désignation: Synaptopodin (SYNPO Produits)

Synonymes: anticorps SYNPO, anticorps DKFZp459N012, anticorps 9030217H17Rik, anticorps 9130229N11, anticorps 9330140I15Rik, anticorps AW046661, anticorps synaptopodin, anticorps formin-like protein 5, anticorps SYNPO, anticorps LOC100147046, anticorps Synpo

Sujet: The spine apparatus (SA) is a specialized form of endoplasmic reticulum (ER) that is found in a subpopulation of dendritic spines in central neurons. The SA consists of a series of stacked discs that are thought to be connected to each other and to the dendritic system of ER-tubules. The actin binding protein synaptopodin (which has originally been described in podocytes of the kidney) is an essential component of the SA. Mice that lack the gene for synaptopodin do not form a spine apparatus. The SA is believed to play a critical role in learning and memory. In summary, an important function of the spine apparatus is the regulation of plasticity at individual synapses, a process known as metaplasticity. The International Radiation Hybrid Mapping Consortium mapped the SYNPO gene to chromosome 5.