ASPSCR1 anticorps
Aperçu rapide pour ASPSCR1 anticorps (ABIN967214)
Antigène
Voir toutes ASPSCR1 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Specificité
- Ni-NTA purified truncated recombinant TUG expressed in E. Coli strain BL21 (DE3)
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Purification
- Antibodies are purified by protein A affinity chromatography
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Isotype
- IgG1
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Indications d'application
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Western Blot: 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test. -
Restrictions
- For Research Use only
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Buffer
- PBS with 0.2%BSA
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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: "Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking." dans: Nature, Vol. 425, Issue 6959, pp. 727-33, (2003) (PubMed).
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- ASPSCR1 (Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1))
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Autre désignation
- TUG
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Sujet
- The TUG protein contains a UBX domain, for GLUT4. In truncated form, TUG acts in a dominantnegative manner to inhibit insulin-stimulated GLUT4 redistribution in Chinese hamster ovary cells and 3T3-L1 adipocytes. Full-length TUG forms a complex specifically with GLUT4. In 3T3-L1 adipocytes, this complex is present in unstimulated cells and is largely disassembled by insulin. Endogenous TUG is localized with the insulin-mobilizable pool of GLUT4 in unstimulated 3T3-L1 adipocytes, and is not mobilized to the plasma membrane by insulin.
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ID gène
- 68938
Antigène
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