TIAL1 anticorps (AA 161-365)

N° du produit ABIN967917

Cet anticorps anti-TIAL1 est un anticorps Souris Monoclonal détectant TIAL1 dans WB, IHC, IP et IF. Adapté pour Humain, Souris, Rat, Chien et Grenouille. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour TIAL1 anticorps (AA 161-365) (ABIN967917)

Antigène: TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))

Reactivité: Humain, Souris, Rat, Chien, Grenouille

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TIAL1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: 6-TIAR

Détail du produit anti-TIAL1 anticorps

Épitope: AA 161-365

Réactivité croisée: Souris, Rat (Rattus), Chien, Grenouille

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human TIAR aa. 161-365

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968555, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-TIAL1 (ABIN967917)

Taupin, Tian, Kedersha, Robertson, Anderson: "The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 5, pp. 1629-33, (1995) (PubMed).

Kawakami, Tian, Duan, Streuli, Schlossman, Anderson: "Identification and functional characterization of a TIA-1-related nucleolysin." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 18, pp. 8681-5, (1992) (PubMed).

Détails sur TIAL1

Antigène: TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))

Autre désignation: TIAR

Sujet: TIAR is an RNA-binding protein related to TIA-1. Both proteins are candidate effectors of apoptotic cell death and consist of three N-terminal RNA-recognition motifs (RRM) and a C-terminal protein-interaction domain (PID). Unlike TIA-1, which is localized in the granules of cytotoxic lymphocytes, TIAR is predominantly found in the nucleus of many different cell types. Two related isoforms (42 kDa and 50 kDa) of TIAR have been identified. It has been demonstrated that TIAR can trigger DNA fragmentation in permeabilized thymocytes, suggesting that it may be an effector of apoptotic cell death. During Fas-mediated apoptosis, TIAR shows a rapid translocation from the nucleus to the cytoplasm. This redistribution of TIAR appears to be a specific event and possibly a general feature of the apoptotic program.

Poids moléculaire: 50 & 42 kDa