DAB2 anticorps (AA 31-45)

N° du produit ABIN967989

Cet anticorps anti-DAB2 est un anticorps Souris Monoclonal détectant DAB2 dans WB, IHC, IF et IP. Adapté pour Humain, Souris et Rat. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour DAB2 anticorps (AA 31-45) (ABIN967989)

Antigène: DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DAB2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 52-p96

Détail du produit anti-DAB2 anticorps

Épitope: AA 31-45

Réactivité croisée: Humain, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse p96 aa. 31-45

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-DAB2 (ABIN967989)

Mishra, Keyel, Hawryluk, Agostinelli, Watkins, Traub: "Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor." dans: The EMBO journal, Vol. 21, Issue 18, pp. 4915-26, (2002) (PubMed).

Hocevar, Smine, Xu, Howe: "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway." dans: The EMBO journal, Vol. 20, Issue 11, pp. 2789-801, (2001) (PubMed).

Smith, Capo-chichi, He, Smedberg, Yang, Prowse, Godwin, Hamilton, Xu: "Disabled-2 mediates c-Fos suppression and the cell growth regulatory activity of retinoic acid in embryonic carcinoma cells." dans: The Journal of biological chemistry, Vol. 276, Issue 50, pp. 47303-10, (2001) (PubMed).

Xu, Yang, Jackowski, Rock: "Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product." dans: The Journal of biological chemistry, Vol. 270, Issue 23, pp. 14184-91, (1995) (PubMed).

Détails sur DAB2

Antigène: DAB2 (Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))

Autre désignation: p96

Sujet: CSF-1 is a growth factor that stimulates the growth and differentiation of immature lymphocytes and is required for the survival of mononuclear phagocytes. Binding of CSF-1 induces dimerization and autophosphorylation of its receptor. This results in the activation of several signal transduction pathways. A unique 96 kDa protein is a component in the CSF-1 signal transduction cascade. p96 is phosphorylated on serine following mitogenic stimulation of a mouse macrophage cell line. p96 contains three potential C-terminal ERK kinase phosphorylation sites, as well as several proline-rich sequences that are potential binding sites for SH3-containing proteins. Structural similarities have been found between p96 and Dab, a product of the Drosophila disabled gene, and p96 was also identified as Disabled-2 (Dab-2) and as differentially expressed in ovarian carcinoma-2 (DOC-2) . Dab-2/p96 has been shown to be essential for TGFbeta signaling by facilitating signal transduction from the TGFbeta receptor to the Smad family of transcription factors. Thus, Dab-2/p96 is an important adaptor molecule in growth factor signaling pathways.
Synonyms: Disabled-2

Poids moléculaire: 96 kDa

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process