MVP anticorps (AA 403-592)

N° du produit ABIN968013

Cet anticorps anti-MVP est un anticorps Souris Monoclonal détectant MVP dans WB, IHC, IF et IP. Adapté pour Humain, Boeuf (Vache), Lapin et Chien. Ce Primary Antibody a été cité dans 5+ publications.

Aperçu rapide pour MVP anticorps (AA 403-592) (ABIN968013)

Antigène: MVP (Major Vault Protein (MVP))

Reactivité: Humain, Boeuf (Vache), Lapin, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MVP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 42-LRP

Détail du produit anti-MVP anticorps

Épitope: AA 403-592

Réactivité croisée: Boeuf (Vache), Chien, Lapin

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human LRP aa. 403-592

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968536

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-MVP (ABIN968013)

Papura: "Managed care policy regarding OMT reimbursement illogical." dans: The Journal of the American Osteopathic Association, Vol. 102, Issue 2, pp. 66, (2002) (PubMed).

Rybarova, Batekova, Hodorova, Mirossay, Kluchova, Bobrov, Kocisova: "Immunohistochemical detection of LRP protein in the normal human lung." dans: Bratislavské lekárske listy, Vol. 102, Issue 2, pp. 66-72, (2001) (PubMed).

List, Spier, Grogan, Johnson, Roe, Greer, Wolff, Broxterman, Scheffer, Scheper, Dalton: "Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia." dans: Blood, Vol. 87, Issue 6, pp. 2464-9, (1996) (PubMed).

Kickhoefer, Rome: "The sequence of a cDNA encoding the major vault protein from Rattus norvegicus." dans: Gene, Vol. 151, Issue 1-2, pp. 257-60, (1995) (PubMed).

Scheffer, Wijngaard, Flens, Izquierdo, Slovak, Pinedo, Meijer, Clevers, Scheper: "The drug resistance-related protein LRP is the human major vault protein." dans: Nature medicine, Vol. 1, Issue 6, pp. 578-82, (1995) (PubMed).

Détails sur MVP

Antigène: MVP (Major Vault Protein (MVP))

Autre désignation: LRP

Sujet: Drugs that selectively attack dividing cells are often used in cancer therapy. However, small cell populations do not die, but develop resistance to a variety of toxic drugs. Multidrug resistance is achieved by gene amplification of specific membrane-bound transport ATPases that shuttle the drugs out of cells. Some multidrug-resistant cancer cells express a protein of 110 kDa named LRP (Lung Resistance-related Protein). LRP expression might be an indicator of prognosis after chemotherapy in acute myeloid leukemia and ovarian carcinoma. The LRP gene encodes a protein of 896 amino acids with significant homology to the major vault protein from Dictyostelium discoideum. Although ubiquitously expressed, LRP is most abundant in epithelial cells.

Poids moléculaire: 110 kDa