Liver Arginase anticorps (AA 53-207)

N° du produit ABIN968127

Détail du produit anti-Liver Arginase anticorps

Antigène: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Épitope: AA 53-207

Reactivité: Rat, Souris, Blow Fly

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Liver Arginase est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Réactivité croisée: Souris, Rat (Rattus), Mouche des fruits (Drosophila melanogaster)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Arginase I aa. 53-207

Clone: 19-Arginase I

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968543, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-Liver Arginase (ABIN968127)

Morrison, Correll: "Activation of the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase by macrophage-stimulating protein results in the induction of arginase activity in murine peritoneal macrophages." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 2, pp. 853-60, (2002) (PubMed).

Chang, Zoghi, Liao, Kuo: "The involvement of tyrosine kinases, cyclic AMP/protein kinase A, and p38 mitogen-activated protein kinase in IL-13-mediated arginase I induction in macrophages: its implications in IL-13-inhibited nitric oxide production." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 4, pp. 2134-41, (2000) (PubMed).

Sonoki, Nagasaki, Gotoh, Takiguchi, Takeya, Matsuzaki, Mori: "Coinduction of nitric-oxide synthase and arginase I in cultured rat peritoneal macrophages and rat tissues in vivo by lipopolysaccharide." dans: The Journal of biological chemistry, Vol. 272, Issue 6, pp. 3689-93, (1997) (PubMed).

Dizikes, Grody, Kern, Cederbaum: "Isolation of human liver arginase cDNA and demonstration of nonhomology between the two human arginase genes." dans: Biochemical and biophysical research communications, Vol. 141, Issue 1, pp. 53-9, (1987) (PubMed).

Haraguchi, Takiguchi, Amaya, Kawamoto, Matsuda, Mori: "Molecular cloning and nucleotide sequence of cDNA for human liver arginase." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 2, pp. 412-5, (1987) (PubMed).

Détails sur Liver Arginase

Antigène: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Autre désignation: Arginase I (ARG1 Produits)

Synonymes: anticorps SI:zC146F4.4 (novel protein with NUDIX domain), anticorps si:ch211-146f4.3, anticorps argi1, anticorps AI, anticorps AI256583, anticorps Arg-1, anticorps PGIF, anticorps arginase 1, anticorps arginase, anticorps Arginase-1, anticorps arginase, liver, anticorps L-arginase, anticorps arg1, anticorps PGTG_16455, anticorps argi1, anticorps ARG1, anticorps Arg1

Sujet: Arginase converts arginine into urea plus ornithine, the final step in urea synthesis. Two different isoforms (I&II) have been isolated with approximately 60% homology at the nucleotide level. While type II is present in many tissues, Arginase I is expressed exclusively in liver. In cultured macrophages, as well as in vivo, Arginase I is induced with nitric oxide synthase (NOS) and the arginase I transactivator C/EBPbeta in response to lipopolysaccharide. This response occurs in a dose and time-dependent manner. While the mRNA for NOS appears as early as 2h after treatment, mRNA levels for arginase I peak after twelve hours of lipopolysaccharide treatment. Since the synthesis of nitric oxide by NOS requires arginine, the delayed induction of arginase I may be necessary for the regulation of NOS activity. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 35 kDa

Pathways: Cellular Response to Molecule of Bacterial Origin