MEF2D anticorps (AA 346-511)

N° du produit ABIN968169

Cet anticorps anti-MEF2D est un anticorps Souris Monoclonal détectant MEF2D dans WB, IHC, IP et IF. Adapté pour Humain, Souris, Rat et Chien. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour MEF2D anticorps (AA 346-511) (ABIN968169)

Antigène: MEF2D (Myocyte Enhancer Factor 2D (MEF2D))

Reactivité: Humain, Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MEF2D est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: 9-MEF2D

Détail du produit anti-MEF2D anticorps

Épitope: AA 346-511

Réactivité croisée: Humain, Rat (Rattus), Chien

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse MEF2D aa. 346-511

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968535, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-MEF2D (ABIN968169)

Guttridge, Mayo, Madrid, Wang, Baldwin: "NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia." dans: Science (New York, N.Y.), Vol. 289, Issue 5488, pp. 2363-6, (2000) (PubMed).

Mora, Pessin: "The MEF2A isoform is required for striated muscle-specific expression of the insulin-responsive GLUT4 glucose transporter." dans: The Journal of biological chemistry, Vol. 275, Issue 21, pp. 16323-8, (2000) (PubMed).

Breitbart, Liang, Smoot, Laheru, Mahdavi, Nadal-Ginard: "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage." dans: Development (Cambridge, England), Vol. 118, Issue 4, pp. 1095-106, (1994) (PubMed).

Martin, Miano, Hustad, Copeland, Jenkins, Olson: "A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing." dans: Molecular and cellular biology, Vol. 14, Issue 3, pp. 1647-56, (1994) (PubMed).

Détails sur MEF2D

Antigène: MEF2D (Myocyte Enhancer Factor 2D (MEF2D))

Autre désignation: MEF2D

Sujet: MEF2D is a member of the MEF2 (Myocyte-specific Enhancer-binding Factor 2) transcription factor family. Members of this family (MEF2A, B, C, & D) contain several characteristic motifs that include a MEF2 domain and a MADS box. MEF2 proteins bind the DNA sequence, 5'- (C/T)T(A/T)(A/T)AAATA(A/G)-3', and binding occurs primarily, although not exclusively, in muscle cells. MEF2D gene expression is ubiquitous and the mRNA is alternatively spliced. This results in multiple protein isoforms that heterodimerize with other family members. In addition to the MEF2 and MADS domains, MEF2D has a glutamine-/proline-rich region, amino acids 365-404, and a basic region, in the MADS domain near the N-terminus. The glutamine-/proline-rich region is involved in transactivation, while the basic region mediates sequence-specific DNA binding. MEF2D displays 75% similarity to hMEF2A and hMEF2C. Myogenin gene transcription requires MEF2D, indicating that MEF2D is involved in myogenesis and muscle cell differentiation. MEF2D has been reported to have a calculated molecular weight of 56 kD, but can be observed migrating in a range of 56-70 kD.
Synonyms: Myocyte-specific Enhancer-binding Factor 2

Poids moléculaire: 56-70 kDa