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BMX anticorps (AA 138-276)

BMX Reactivité: Humain, Souris, Poulet WB, IHC, IF, IP Hôte: Souris Monoclonal 40-BMX unconjugated
N° du produit ABIN968180
  • Antigène Voir toutes BMX Anticorps
    BMX (BMX Non-Receptor Tyrosine Kinase (BMX))
    Épitope
    • 20
    • 19
    • 7
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 138-276
    Reactivité
    • 59
    • 50
    • 21
    • 5
    • 1
    • 1
    • 1
    Humain, Souris, Poulet
    Hôte
    • 73
    • 2
    Souris
    Clonalité
    • 73
    • 2
    Monoclonal
    Conjugué
    • 42
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp BMX est non-conjugé
    Application
    • 72
    • 37
    • 34
    • 26
    • 26
    • 21
    • 16
    • 7
    • 5
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
     Réactivité croisée
    Souris, Poulet
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human BMX aa. 138-276
    Clone
    40-BMX
    Isotype
    IgG1
    Top Product
    Discover our top product BMX Anticorps primaire
  • Commentaires

    Related Products: ABIN968537, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Vargas, Nore, Berglof, Heinonen, Mattsson, Smith, Mohamed: "Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx." dans: The Journal of biological chemistry, Vol. 277, Issue 11, pp. 9351-7, (2002) (PubMed).

    Rajantie, Ekman, Iljin, Arighi, Gunji, Kaukonen, Palotie, Dewerchin, Carmeliet, Alitalo: "Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium." dans: Molecular and cellular biology, Vol. 21, Issue 14, pp. 4647-55, (2001) (PubMed).

    Kaukonen, Lahtinen, Laine, Alitalo, Palotie: "BMX tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias." dans: British journal of haematology, Vol. 94, Issue 3, pp. 455-60, (1996) (PubMed).

    Tamagnone, Lahtinen, Mustonen, Virtaneva, Francis, Muscatelli, Alitalo, Smith, Larsson, Alitalo: "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2." dans: Oncogene, Vol. 9, Issue 12, pp. 3683-8, (1994) (PubMed).

  • Antigène
    BMX (BMX Non-Receptor Tyrosine Kinase (BMX))
    Autre désignation
    BMX (BMX Produits)
    Synonymes
    anticorps BMX, anticorps ETK, anticorps PSCTK2, anticorps PSCTK3, anticorps Etk, anticorps Etk/Bmx, anticorps Tyro8, anticorps RGD1565643, anticorps BMX non-receptor tyrosine kinase, anticorps BMX, anticorps bmx, anticorps Bmx
    Sujet
    BMX (bone marrow X kinase) is a cytoplasmic tyrosine kinase identified by reverse transcription of mRNA isolated from human bone marrow and mapped to the chromosomal band Xp22.2. The full length protein is 675 amino acids with a tyrosine kinase domain, an amino terminal pleckstrin domain, as well as an SH3 and SH2 domain. Direct comparison of BMX's primary sequence with other kinases showed that this is highly related to the family of BTK/ITK/TEC. BMX kinase is expressed in fetal and adult tissues, with the highest expression in heart, testis, small intestine and colon. It is undetectable in spleen, brain, kidney, and pancreas. Further analysis of mRNA expression showed that BMX is expressed in hematopoietic tissues and neutrophilic granulocytes, and in patients with acute and myeloid leukemia. The levels of BMX mRNA were substantially lower in patients with acute and chronic lymphoid leukemias, thus suggesting that BMX may be important during myelopoiesis. This antibody is routinely tested by western blot analysis.
    Poids moléculaire
    80 kDa
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