Utrophin anticorps (AA 768-874)

N° du produit ABIN968237

L’anticorps Souris Monoclonal anti-Utrophin a été validé pour WB et IF. Il convient pour détecter Utrophin dans des échantillons de Souris. Il y a 5+ publications disponibles.

Aperçu rapide pour Utrophin anticorps (AA 768-874) (ABIN968237)

Antigène: Utrophin (UTRN)

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Utrophin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 55-Utrophin

Détail du produit anti-Utrophin anticorps

Épitope: AA 768-874

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse Utrophin aa. 768-874

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-Utrophin (ABIN968237)

Gramolini, Burton, Tinsley, Ferns, Cartaud, Cartaud, Davies, Lunde, Jasmin: "Muscle and neural isoforms of agrin increase utrophin expression in cultured myotubes via a transcriptional regulatory mechanism." dans: The Journal of biological chemistry, Vol. 273, Issue 2, pp. 736-43, (1998) (PubMed).

Deconinck, Rafael, Skinner, Brown, Potter, Metzinger, Watt, Dickson, Tinsley, Davies: "Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy." dans: Cell, Vol. 90, Issue 4, pp. 717-27, (1997) (PubMed).

Grady, Teng, Nichol, Cunningham, Wilkinson, Sanes: "Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy." dans: Cell, Vol. 90, Issue 4, pp. 729-38, (1997) (PubMed).

Guo, Nichol, Merlie: "Cloning and expression of full length mouse utrophin: the differential association of utrophin and dystrophin with AChR clusters." dans: FEBS letters, Vol. 398, Issue 2-3, pp. 259-64, (1997) (PubMed).

Tinsley, Blake, Roche, Fairbrother, Riss, Byth, Knight, Kendrick-Jones, Suthers, Love: "Primary structure of dystrophin-related protein." dans: Nature, Vol. 360, Issue 6404, pp. 591-3, (1993) (PubMed).

Détails sur Utrophin

Antigène: Utrophin (UTRN)

Autre désignation: Utrophin

Sujet: Utrophin is an autosomal homolog of dystrophin located on chromosome 6q24. Both encode large cytoskeletal proteins that are members of the spectrin superfamily. Spectrin family proteins are located at the cytoplasmic face and link the intracellular cytoskeleton to the extracellular matrix. Utrophin is nearly identical to dystrophin, specifically in the N-terminal actin binding domain and the C-terminus. Dystrophin is expressed primarily in the brain and muscle, while Utrophin is ubiquitously expressed. In skeletal muscle, Utrophin expression varies depending on the the state of differentiation and innervation of muscle fibers. During development, it localizes in the sarcolemma. Following formation of synaptic contacts, Utrophin is found within the postsynaptic membrane domain of the neuromuscular junction. However, its expression is not limited to postsynaptic compartments. Although dystrophin is absent in patients with Duchenne muscular dystrophy (DMD) and mdx (dystrophin deficient) mice, Utrophin is upregulated. The regulation mechanisms underlying Utrophin expression in muscle have yet to be determined.

Poids moléculaire: 400 kDa

Pathways: Skeletal Muscle Fiber Development