BIRC6 anticorps (AA 372-571)

N° du produit ABIN968409

Cet anticorps anti-BIRC6 est un anticorps Souris Monoclonal détectant BIRC6 dans WB et IF. Adapté pour Humain, Souris, Chien et Rat. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour BIRC6 anticorps (AA 372-571) (ABIN968409)

Antigène: BIRC6 (Baculoviral IAP Repeat-Containing 6 (BIRC6))

Reactivité: Humain, Souris, Chien, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BIRC6 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 4-BRUCE

Détail du produit anti-BIRC6 anticorps

Épitope: AA 372-571

Réactivité croisée: Humain, Rat (Rattus), Chien

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse BRUCE aa. 372-571

Isotype: IgG1

Information d'application

Indications d'application: Clone 4/BRUCE has also been shown to work well for Western blot application on Hela lysate (ABIN968535)

Commentaires:

Related Products: ABIN968552, ABIN967389, ABIN968535

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-BIRC6 (ABIN968409)

Hauser, Bardroff, Pyrowolakis, Jentsch: "A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors." dans: The Journal of cell biology, Vol. 141, Issue 6, pp. 1415-22, (1998) (PubMed).

Détails sur BIRC6

Antigène: BIRC6 (Baculoviral IAP Repeat-Containing 6 (BIRC6))

Autre désignation: BRUCE

Sujet: Selective proteolysis is essential for the modulation of key cellular processes such as cell cycle progression. However, unlike other post-translational events, proteolysis is irreversible and therefore must occur in unidirectional cellular pathways. In eukaryotes, proteolysis is mediated primarily by the ubiquitin pathway. This pathway designates proteins for degradation by the proteasome, a multicatalytic protease complex. The ubiquitin pathway is a multistep system that tags proteins for degradation via the attachment of ubiquitin molecules to the target. This attachment is mediated by the ubiquitin activating/conjugating enzymes E1, E2, E3, and BRUCE. BRUCE (BIR Repeat containing Ubiquitin-Conjugating Enzyme) is a novel enzyme that associates with the Golgi and the vesicular system. It contains a UBC (ubiquitin conjugating enzyme) domain, which is essential for catalysis, and a BIR (baculovirus inhibitor of apoptosis repeat) motif. BIR motifs are also found within inhibitor of apoptosis proteins (IAP) and are critical for anti-apoptotic activity. Therefore, BRUCE may function to both mediate ubiquitin-dependent proteolysis and contribute to anti-apoptotic cellular pathways.
Synonyms: BIR Repeat containing Ubiquitin-Conjugating Enzyme

Poids moléculaire: 528 kDa