Aldehyde Dehydrogenase anticorps (AA 7-128)

N° du produit ABIN968411

L’anticorps Souris Monoclonal anti-Aldehyde Dehydrogenase a été validé pour WB, IF et IHC. Il convient pour détecter Aldehyde Dehydrogenase dans des échantillons de Humain. Il y a 4+ publications disponibles.

Aperçu rapide pour Aldehyde Dehydrogenase anticorps (AA 7-128) (ABIN968411)

Antigène: Aldehyde Dehydrogenase (ALDH)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Aldehyde Dehydrogenase est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Clone: 44-ALDH

Détail du produit anti-Aldehyde Dehydrogenase anticorps

Épitope: AA 7-128

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human ALDH1 aa. 7-128

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968533

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-Aldehyde Dehydrogenase (ABIN968411)

Zhou, Hanna, Roberts, Weber, Bell: "ALDH1 immunohistochemical expression and its significance in salivary adenoid cystic carcinoma." dans: Head & neck, Vol. 35, Issue 4, pp. 575-8, (2013) (PubMed).

Greene, Bahn, Masson, Rabbitts: "The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development." dans: Molecular and cellular biology, Vol. 18, Issue 12, pp. 7030-7, (1998) (PubMed).

Yoshida, Rzhetsky, Hsu, Chang: "Human aldehyde dehydrogenase gene family." dans: European journal of biochemistry / FEBS, Vol. 251, Issue 3, pp. 549-57, (1998) (PubMed).

Kathmann, Lipsky: "Cloning of a cDNA encoding a constitutively expressed rat liver cytosolic aldehyde dehydrogenase." dans: Biochemical and biophysical research communications, Vol. 236, Issue 2, pp. 527-31, (1997) (PubMed).

Détails sur Aldehyde Dehydrogenase

Antigène: Aldehyde Dehydrogenase (ALDH)

Autre désignation: ALDH

Sujet: Aldehyde dehydrogenase (ALDH) is a ubiquitous enzyme located in nearly all mammalian tissues. It catalyzes the irreversible oxidation of a range of aliphatic and aromatic aldehydes to their corresponding carboxylic acids. There are multiple isoforms of ALDH which are subdivided into three classes. Class I includes the cytosolic isoforms. Class II includes the mitochondrial isoforms. Class III includes the microsomal, cytosolic tumor specific, and cytosolic dioxin-inducible forms. At least twelve human ALDH isoforms have been identified. Mutations of many of these proteins such as ALDH1, ALDH2, ALDH4, and ALDH10 have been implicated in multiple human metabolic disorders and clinical abnormalities. At the amino acid level, human ALDH isoforms exhibit a wide range of diversity (15% to about 80%). However, multiple protein regions have been highly conserved and are important for functional activities. A well-characterized member of the human ALDH family is ALDH1. It plays a major role in the biosynthesis of retinoic acid from retinol (vitamin A). Retinoic acid, the biologically active form of retinol, is a regulator of cellular proliferation, differentiation, and survival.

Poids moléculaire: 55 kDa