STX8 anticorps (AA 57-164)

N° du produit ABIN968489

L’anticorps Souris Monoclonal anti-STX8 a été validé pour WB et IF. Il convient pour détecter STX8 dans des échantillons de Humain, Souris, Rat et Chien. Il y a 2+ publications disponibles.

Aperçu rapide pour STX8 anticorps (AA 57-164) (ABIN968489)

Antigène: STX8 (Syntaxin 8 (STX8))

Reactivité: Humain, Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp STX8 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 48-Syntaxin 8

Détail du produit anti-STX8 anticorps

Épitope: AA 57-164

Réactivité croisée: Humain, Chien, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse Syntaxin 8 aa. 57-164

Isotype: IgG2a

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968536

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-STX8 (ABIN968489)

Steegmaier, Yang, Yoo, Huang, Shen, Yu, Luo, Scheller: "Three novel proteins of the syntaxin/SNAP-25 family." dans: The Journal of biological chemistry, Vol. 273, Issue 51, pp. 34171-9, (1999) (PubMed).

Thoreau, Bergès, Callebaut, Guillier-Gencik, Gressin, Bernheim, Karst, Mornon, Kitzis, Chomel: "Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8)." dans: Biochemical and biophysical research communications, Vol. 257, Issue 2, pp. 577-83, (1999) (PubMed).

Détails sur STX8

Antigène: STX8 (Syntaxin 8 (STX8))

Autre désignation: Syntaxin 8

Sujet: Eukaryotic protein trafficking involves the packaging of molecules into membranous vesicles that bud from a donor compartment, travel to a specific destination, fuse, and release their components into an acceptor compartment. Recognition between vesicle and acceptor membrane is mediated by the pairing of the integral membrane SNARE proteins. The stable interaction between vesicle proteins (v-SNAREs) and target proteins (t-SNAREs) juxtaposes the membranes and results in an activated docking state and/or membrane fusion. The syntaxin protein family contains a number of members that serve as functional t-SNAREs. One member of this family, syntaxin 8, has two coiled-coil domains, one in the N-terminus and one toward the C-terminus. The C-terminal domain is homologous to a similar domain in syntaxin 6 and is predicted to interact in the formation of SNARE complexes, while a hydrophobic domain in the C-terminus may be involved in membrane anchoring. Syntaxin-8 is ubiquitously expressed, but is present at high levels in the heart and localizes specifically to the ER. Thus, syntaxin-8 is a t-SNARE that is thought to be involved in the early secretory pathway of many different cell types.

Poids moléculaire: 27 kDa

Pathways: Synaptic Vesicle Exocytosis