Sorting Nexin 1 anticorps (AA 1-108)

N° du produit ABIN968558

L’anticorps Souris Monoclonal anti-Sorting Nexin 1 a été validé pour WB et IF. Il convient pour détecter Sorting Nexin 1 dans des échantillons de Humain. Il y a 4+ publications disponibles.

Aperçu rapide pour Sorting Nexin 1 anticorps (AA 1-108) (ABIN968558)

Antigène: Sorting Nexin 1 (SNX1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Sorting Nexin 1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 51-SNX1

Détail du produit anti-Sorting Nexin 1 anticorps

Épitope: AA 1-108

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human SNX1 aa. 1-108

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968535

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-Sorting Nexin 1 (ABIN968558)

Cozier, Carlton, McGregor, Gleeson, Teasdale, Mellor, Cullen: "The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation." dans: The Journal of biological chemistry, Vol. 277, Issue 50, pp. 48730-6, (2002) (PubMed).

Strehlow, Jelaska, Strehlow, Korn: "A potential role for protease nexin 1 overexpression in the pathogenesis of scleroderma." dans: The Journal of clinical investigation, Vol. 103, Issue 8, pp. 1179-90, (1999) (PubMed).

Haft, de la Luz Sierra, Barr, Haft, Taylor: "Identification of a family of sorting nexin molecules and characterization of their association with receptors." dans: Molecular and cellular biology, Vol. 18, Issue 12, pp. 7278-87, (1998) (PubMed).

Kurten, Cadena, Gill: "Enhanced degradation of EGF receptors by a sorting nexin, SNX1." dans: Science (New York, N.Y.), Vol. 272, Issue 5264, pp. 1008-10, (1996) (PubMed).

Détails sur Sorting Nexin 1

Antigène: Sorting Nexin 1 (SNX1)

Autre désignation: SNX1

Sujet: Biological processes such as transmembrane signaling and receptor mediated endocytosis revolve around the function of cell surface receptors. A network of molecular machinery directs the intracellular trafficking of receptors during their biosynthesis and mediates signaling downstream of receptors. The sorting nexins (SNX1, SNX1A, SNX2, SNX3, and SNX4) are a family of intracellular proteins that are thought to direct the sorting of receptor proteins. The SNX proteins contain a conserved 100 amino acid region termed the phox homology (PX) domain and are part of a family of hydrophilic proteins which includes S. cerevisiae proteins that function in protein sorting. SNX1, SNX2, and SNX4 associate predominantly with membranes and bind transmembrane receptors such as those for EGF, PDGF, and insulin. SNX1 directs the EGF receptor to the lysosomes for degradation. SNX2 forms homomeric complexes and heteromeric complexes with SNX1, SNX1A, and SNX4. These complexes are thought to be necessary for efficient protein sorting. Thus, SNX1 and other sorting nexins are thought to play important roles in the specificity of protein trafficking to and from the plasma membrane.

Poids moléculaire: 74 kDa