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ARHGAP5 anticorps (AA 1102-1214)

ARHGAP5 Reactivité: Humain, Rat, Chien WB, IF Hôte: Souris Monoclonal 54-P190 unconjugated
N° du produit ABIN968611
  • Antigène Voir toutes ARHGAP5 Anticorps
    ARHGAP5 (rho GTPase Activating Protein 5 (ARHGAP5))
    Épitope
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1102-1214
    Reactivité
    • 21
    • 8
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Chien
    Hôte
    • 21
    Souris
    Clonalité
    • 19
    • 1
    Monoclonal
    Conjugué
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ARHGAP5 est non-conjugé
    Application
    • 13
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Rat (Rattus), Chien
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human p190-B aa. 1102-1214
    Clone
    54-P190
    Isotype
    IgG1
    Top Product
    Discover our top product ARHGAP5 Anticorps primaire
  • Commentaires

    Related Products: ABIN968533, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Burbelo, Finegold, Kozak, Yamada, Takami: "Cloning, genomic organization and chromosomal assignment of the mouse p190-B gene." dans: Biochimica et biophysica acta, Vol. 1443, Issue 1-2, pp. 203-10, (1999) (PubMed).

    Burbelo, Miyamoto, Utani, Brill, Yamada, Hall, Yamada: "p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking." dans: The Journal of biological chemistry, Vol. 270, Issue 52, pp. 30919-26, (1996) (PubMed).

  • Antigène
    ARHGAP5 (rho GTPase Activating Protein 5 (ARHGAP5))
    Autre désignation
    p190-B (ARHGAP5 Produits)
    Synonymes
    anticorps gfi2, anticorps p190-b, anticorps rhogap5, anticorps p190brhogap, anticorps GFI2, anticorps RhoGAP5, anticorps p190-B, anticorps p190BRhoGAP, anticorps p190B, anticorps LRRGT00098, anticorps Rho GTPase activating protein 5, anticorps ARHGAP5, anticorps arhgap5, anticorps Arhgap5
    Sujet
    GTPase activating proteins (GAPs) stimulate the GTP-hydrolyzing activity of GTPases, such as p21ras and Rho. p190-A is a Ras-GAP associated protein that is tyrosine phosphorylated in transformed and growth factor-stimulated cells. Ras-GAP and p190-A are targets of oncoproteins and growth factor receptors. p190-B is another Ras-GAP in the p190 family. It has 51% identity with p190-A and contains several GTPase-related domains in the N-terminal region and a Rho-GAP domain in the C-terminal region. p190-B is expressed in kidney, brain, liver, and lung, as well as in human foreskin fibroblasts, RD muscle cells, and HT-1080 cells. In fibroblasts, p190-B is localized diffusely in the cytoplasm and co-localizes with the alpha5beta1 integrin receptor for fibronectin. Adhesion of fibronectin-coated latex beads to cells leads to the recruitment of p190-B and Rho to the plasma membrane at sites of bead contact. In addition, the recombinant Rho-GAP domain of p190-B displays GAP activity for RhoA, Rac1, and G25K/CDC42Hs. Thus, p190-B is thought to act as a transmembrane link between integrins and Rho GTPases during fibronectin-induced changes in cell morphology and motility.
    Poids moléculaire
    190 kDa
    Pathways
    Regulation of Cell Size
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