EZH2 anticorps (AA 156-256)
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- Antigène Voir toutes EZH2 Anticorps
- EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
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Épitope
- AA 156-256
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Reactivité
- Humain, Souris, Rat, Chien, Poulet
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp EZH2 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Réactivité croisée
- Chien, Rat (Rattus), Souris, Poulet
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Human EZH2 recombinant protein aa. 156-256
- Clone
- 11-EZH2
- Isotype
- IgG1
- Top Product
- Discover our top product EZH2 Anticorps primaire
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- Commentaires
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Related Products: ABIN968537, ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20°C.
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Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 10, pp. 5925-34, (2001) (PubMed).
: "Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma." dans: Blood, Vol. 97, Issue 12, pp. 3896-901, (2001) (PubMed).
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Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 10, pp. 5925-34, (2001) (PubMed).
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- Antigène
- EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
- Autre désignation
- EZH2 (EZH2 Produits)
- Synonymes
- anticorps ENX-1, anticorps ENX1, anticorps EZH1, anticorps EZH2b, anticorps KMT6, anticorps KMT6A, anticorps WVS, anticorps WVS2, anticorps eya2, anticorps im:7149338, anticorps zgc:136376, anticorps zgc:152758, anticorps EZH2, anticorps enx-1, anticorps enx1, anticorps ezh1, anticorps kmt6, anticorps xez, anticorps Enx-1, anticorps Enx1h, anticorps mKIAA4065, anticorps ezh2, anticorps olezh2, anticorps enhancer of zeste 2 polycomb repressive complex 2 subunit, anticorps enhancer of zeste 2 polycomb repressive complex 2 subunit L homeolog, anticorps enhancer of zeste 2 polycomb repressive complex 2 subunit S homeolog, anticorps EZH2, anticorps ezh2, anticorps Ezh2, anticorps ezh2.L, anticorps ezh2.S
- Sujet
- The 11/EZH2 monoclonal antibody specifically binds to the methyltransferase, EZH2 (Enhancer of Zeste Homolog 2). EZH2 is a human homologue of Drosophila's Enhancer of zeste gene, an important regulator of homeobox gene expression. The EZH2 protein has a predicted molecular weight of ~85 kDa. EZH2 is a member of the Polycomb group (PcG) of proteins that are essential for the maintenance, but not initiation, of the transcriptionally repressed state of certain developmental genes. PcG proteins are a structurally diverse group of proteins with conserved functions from fly to human cells. PcG family proteins form multimeric complexes that regulate the expression of genes involved in cell cycle, DNA repair and differentiation. Specifically, EZH2 is a core enzymatic component of PRC2 (polycomb repressive complex 2). EZH2 is expressed in some lymph node follicular T cells and B cells. Thymocytes differentially express EZH2 at various stages during T-cell maturation. EZH2 interacts with multiple signaling proteins, including Vav, that are involved in lymphocyte development and activation. It is highly expressed in a variety of tumors including lymphomas as well as breast and prostate cancers. EZH2 is important in the self renewal and proliferation of numerous stem cell types including fetal hematopoietic stem cells, muscle satellite cells, hepatic stem/progenitor cells, neural stem cells, basal cell progenitors in the developing epidermis, embryonic stem cells, and some cancer stem cells.
- Poids moléculaire
- 91 kDa
- Pathways
- Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation
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