ABL2 anticorps

N° du produit ABIN968944

Cet anticorps Souris Monoclonal détecte spécifiquement ABL2 dans ELISA et ICC. Il présente une réactivité envers Humain et Souris et a été mentionné dans 2+ publications.

Aperçu rapide pour ABL2 anticorps (ABIN968944)

Antigène: ABL2

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ABL2 est non-conjugé

Application: ELISA, Immunocytochemistry (ICC)

Clone: 1H1

Détail du produit anti-ABL2 anticorps

Fonction: ABL2 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of ABL2 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-ABL2 (ABIN968944)

Scheijen, Griffin: "Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease." dans: Oncogene, Vol. 21, Issue 21, pp. 3314-33, (2002) (PubMed).

Iijima, Ito, Oikawa, Eguchi, Eguchi-Ishimae, Kamada, Kishi, Asano, Sakaki, Sato: "A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation." dans: Blood, Vol. 95, Issue 6, pp. 2126-31, (2000) (PubMed).

Détails sur ABL2

Antigène: ABL2

Autre désignation: ABL2

Sujet: ABL2 (ARG, Abl-related gene), together with c-Abl, forms the Abl family of mammalian non-receptor tyrosine kinases. ABL2 and c-Abl share 89 % , 90 and 93 % identity in their SH3, SH2 and tyrosine domain, but only 29 % identity in the carboxy-terminal half. The human c-Abl and ABL2 genes are expressed ubiquitously. ABL2 had been detected predominantly in the cytoplasm, whereas c-Abl shows both cytoplasmic and nuclear localization. c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl. Recently, TEL-ARG fusion transcripts have also been identified in acute myeloid leukemias (AML). The Abl family kinases may also interact with receptor tyrosine signaling pathways and regulate cellular function such as cell cycle progression, gene transcription and organization of the actin cytoskeletons in neurons.

Poids moléculaire: 128 kDa

ID gène: 27

UniProt: P42684