B-Cell Linker anticorps

N° du produit ABIN968984

L’anticorps Souris Monoclonal anti-B-Cell Linker a été validé pour WB, ELISA, IHC, FACS et ICC. Il convient pour détecter B-Cell Linker dans des échantillons de Humain et Souris. Il y a 2+ publications disponibles.

Aperçu rapide pour B-Cell Linker anticorps (ABIN968984)

Antigène: B-Cell Linker (BLNK)

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp B-Cell Linker est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 5G9

Détail du produit anti-B-Cell Linker anticorps

Fonction: BLNK Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human BLNK expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-B-Cell Linker (ABIN968984)

Imamura, Oda, Katahira, Bundo, Pike, Ratcliffe, Kitamura: "BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation." dans: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9804-13, (2009) (PubMed).

Kamino, Futamura, Nakamura, Kitamura, Kabu, Arakawa: "B-cell linker protein prevents aneuploidy by inhibiting cytokinesis." dans: Cancer science, Vol. 99, Issue 12, pp. 2444-54, (2008) (PubMed).

Détails sur B-Cell Linker

Antigène: B-Cell Linker (BLNK)

Autre désignation: BLNK

Sujet: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 68 kDa

UniProt: Q8WV28

Pathways: BCR Signaling