N-Cadherin anticorps

N° du produit ABIN969038

L’anticorps Souris Monoclonal anti-N-Cadherin a été validé pour WB, IHC, FACS, ELISA et ICC. Il convient pour détecter N-Cadherin dans des échantillons de Humain, Souris et Rat. Il y a 2+ publications disponibles.

Aperçu rapide pour N-Cadherin anticorps (ABIN969038)

Antigène: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp N-Cadherin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC)

Clone: 5D5

Détail du produit anti-N-Cadherin anticorps

Fonction: CDH2 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human CDH2 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-N-Cadherin (ABIN969038)

Wallerand, Cai, Wainberg, Garraway, Lascombe, Nicolle, Thiery, Bittard, Radvanyi, Reiter: "Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines." dans: Urologic oncology, Vol. 28, Issue 2, pp. 180-8, (2010) (PubMed).

Sharma, Henderson: "IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli." dans: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 8545-56, (2007) (PubMed).

Détails sur N-Cadherin

Antigène: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Autre désignation: CDH2

Sujet: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

Poids moléculaire: 99.8 kDa

UniProt: P19022

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane