CTCF anticorps

N° du produit ABIN969071

L’anticorps Souris Monoclonal anti-CTCF a été validé pour WB et ELISA. Il convient pour détecter CTCF dans des échantillons de Humain et Singe. Il y a 3+ publications disponibles.

Aperçu rapide pour CTCF anticorps (ABIN969071)

Antigène: CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CTCF est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 1D11

Détail du produit anti-CTCF anticorps

Fonction: CTCF Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human CTCF expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-CTCF (ABIN969071)

Grbesa, Marinkovic, Ivkic, Kruslin, Novak-Kujundzic, Pegan, Bogdanovic, Bedekovic, Gall-Troselj: "Loss of imprinting of IGF2 and H19, loss of heterozygosity of IGF2R and CTCF, and Helicobacter pylori infection in laryngeal squamous cell carcinoma." dans: Journal of molecular medicine (Berlin, Germany), Vol. 86, Issue 9, pp. 1057-66, (2008) (PubMed).

Majumder, Gomez, Chadwick, Boss: "The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions." dans: The Journal of experimental medicine, Vol. 205, Issue 4, pp. 785-98, (2008) (PubMed).

Stedman, Kang, Lin, Kissil, Bartolomei, Lieberman: "Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulators." dans: The EMBO journal, Vol. 27, Issue 4, pp. 654-66, (2008) (PubMed).

Détails sur CTCF

Antigène: CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))

Autre désignation: CTCF

Sujet: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.Tissue specificity: Ubiquitous. Absent in primary spermatocytes.

Poids moléculaire: 83 kDa

UniProt: P49711