FGG anticorps

N° du produit ABIN969142

Cet anticorps Souris Monoclonal détecte spécifiquement FGG dans IHC, ICC, ELISA et FACS. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour FGG anticorps (ABIN969142)

Antigène: FGG (Fibrinogen gamma Chain (FGG))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FGG est non-conjugé

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC), ELISA, Flow Cytometry (FACS)

Clone: 4H9

Détail du produit anti-FGG anticorps

Fonction: FGG Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human FGG expressed in E. Coli.

Isotype: IgG2a

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-FGG (ABIN969142)

Uitte de Willige, Standeven, Philippou, Ariëns: "The pleiotropic role of the fibrinogen gamma' chain in hemostasis." dans: Blood, Vol. 114, Issue 19, pp. 3994-4001, (2009) (PubMed).

Bowley, Okumura, Lord: "Impaired protofibril formation in fibrinogen gamma N308K is due to altered D:D and "A:a" interactions." dans: Biochemistry, Vol. 48, Issue 36, pp. 8656-63, (2009) (PubMed).

Détails sur FGG

Antigène: FGG (Fibrinogen gamma Chain (FGG))

Autre désignation: FGG

Sujet: The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.

Poids moléculaire: 52 kDa

ID gène: 2266

UniProt: P02679