GATA4 anticorps

N° du produit ABIN969169

Cet anticorps Souris Monoclonal détecte spécifiquement GATA4 dans WB et ELISA. Il présente une réactivité envers Humain et Rat et a été mentionné dans 2+ publications.

Aperçu rapide pour GATA4 anticorps (ABIN969169)

Antigène: GATA4 (GATA Binding Protein 4 (GATA4))

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GATA4 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 6H10

Détail du produit anti-GATA4 anticorps

Fonction: GATA4 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human GATA4 expressed in E. Coli.

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-GATA4 (ABIN969169)

Rajagopal, Ma, Obler, Shen, Manichaikul, Tomita-Mitchell, Boardman, Briggs, Garg, Srivastava, Goldmuntz, Broman, Benson, Smoot, Pu: "Spectrum of heart disease associated with murine and human GATA4 mutation." dans: Journal of molecular and cellular cardiology, Vol. 43, Issue 6, pp. 677-85, (2007) (PubMed).

Belaguli, Sepulveda, Nigam, Charron, Nemer, Schwartz: "Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators." dans: Molecular and cellular biology, Vol. 20, Issue 20, pp. 7550-8, (2000) (PubMed).

Détails sur GATA4

Antigène: GATA4 (GATA Binding Protein 4 (GATA4))

Autre désignation: GATA4

Sujet: GATA binding protein 4, also known as GATA4, it is a 46 kDa member of the GATA family of zinc-finger transcription factors. Members of this family is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. These factors recognize the GATA motif which is present in the promoters of many genes. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.

Poids moléculaire: 46 kDa

ID gène: 2626

UniProt: P43694

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis