GFI1 anticorps

N° du produit ABIN969174

Cet anticorps anti-GFI1 est un anticorps Souris Monoclonal détectant GFI1 dans ELISA. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour GFI1 anticorps (ABIN969174)

Antigène: GFI1 (Growth Factor Independent 1 (GFI1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GFI1 est non-conjugé

Application: ELISA

Clone: 5D7

Détail du produit anti-GFI1 anticorps

Fonction: GFI1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human GFI1 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-GFI1 (ABIN969174)

Dwivedi, Anderson, Tilley, May, Morris: "Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells." dans: The Journal of steroid biochemistry and molecular biology, Vol. 103, Issue 3-5, pp. 742-6, (2007) (PubMed).

Kimura, Wakamatsu, Suzuki, Ota, Nishikawa, Yamashita, Yamamoto, Sekine, Tsuritani, Wakaguri, Ishii, Sugiyama, Saito, Isono, Irie, Kushida, Yoneyama, Otsuka, Kanda, Yokoi, Kondo, Wagatsuma, Murakawa et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." dans: Genome research, Vol. 16, Issue 1, pp. 55-65, (2006) (PubMed).

Détails sur GFI1

Antigène: GFI1 (Growth Factor Independent 1 (GFI1))

Autre désignation: GFI1

Sujet: This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.Expression of GFl1 ranges from the hematopoietic and lymphoid system, to sensory epithelia, lung and parts of the CNS.

Poids moléculaire: 45 kDa

ID gène: 2672

UniProt: Q99684