GPI anticorps

N° du produit ABIN969176

L’anticorps Souris Monoclonal anti-GPI a été validé pour ELISA, IHC et ICC. Il convient pour détecter GPI dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour GPI anticorps (ABIN969176)

Antigène: GPI (Glucose-6-Phosphate Isomerase (GPI))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GPI est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: 1B7D7

Détail du produit anti-GPI anticorps

Fonction: Glucose-6-phosphate isomerase Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human GPI expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-GPI (ABIN969176)

Schaller, Stohl, Benoit, Tan, Johansen, Ditzel: "Patients with inflammatory arthritic diseases harbor elevated serum and synovial fluid levels of free and immune-complexed glucose-6-phosphate isomerase (G6PI)." dans: Biochemical and biophysical research communications, Vol. 349, Issue 2, pp. 838-45, (2006) (PubMed).

Haga, Komazaki, Funasaka, Hashimoto, Yokoyama, Watanabe, Raz, Nagase: "AMF/G6PI induces differentiation of leukemic cells via an unknown receptor that differs from gp78." dans: Leukemia & lymphoma, Vol. 47, Issue 10, pp. 2234-43, (2006) (PubMed).

Muraki, Matsumoto, Chino, Hayashi, Suzuki, Goto, Ito, Murata, Tsutsumi, Sumida: "Glucose-6-phosphate isomerase variants play a key role in the generation of anti-GPI antibodies: possible mechanism of autoantibody production." dans: Biochemical and biophysical research communications, Vol. 323, Issue 2, pp. 518-22, (2004) (PubMed).

Détails sur GPI

Antigène: GPI (Glucose-6-Phosphate Isomerase (GPI))

Autre désignation: Glucose-6-phosphate isomerase

Sujet: Glucose-6-phosphate isomerase, or phosphoglucose isomerase, also known as GPI. It belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways and it is an enzyme that catalyzes the conversion of glucose-6-phosphate into fructose 6-phosphate in the second step of glycolysis. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in GPI are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.

Poids moléculaire: 63 kDa

ID gène: 2821

UniProt: P06744