IHOG anticorps

N° du produit ABIN969211

Cet anticorps Souris Monoclonal détecte spécifiquement IHOG dans ELISA. Il présente une réactivité envers Drosophila melanogaster et a été mentionné dans 1 publication.

Aperçu rapide pour IHOG anticorps (ABIN969211)

Antigène: IHOG (Interference Hedgehog (IHOG))

Reactivité: Drosophila melanogaster

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IHOG est non-conjugé

Application: ELISA

Clone: 3G8

Détail du produit anti-IHOG anticorps

Fonction: IHOG Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human IHOG expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-IHOG (ABIN969211)

McLellan, Yao, Zheng, Geisbrecht, Ghirlando, Beachy, Leahy: "Structure of a heparin-dependent complex of Hedgehog and Ihog." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 46, pp. 17208-13, (2006) (PubMed).

Détails sur IHOG

Antigène: IHOG (Interference Hedgehog (IHOG))

Autre désignation: IHOG

Sujet: The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.

Poids moléculaire: 98 kDa

ID gène: 33972

UniProt: Q9VM64