KCNQ1 anticorps

N° du produit ABIN969227

Il existe 1 publication pour ce produit. L’anticorps anti-KCNQ1 Monoclonal Souris est utilisé pour la détection de KCNQ1 dans des échantillons de Humain. Il a été validé pour WB, ELISA et FACS.

Aperçu rapide pour KCNQ1 anticorps (ABIN969227)

Antigène: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KCNQ1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 5E12

Détail du produit anti-KCNQ1 anticorps

Fonction: KCNQ1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human KCNQ1 expressed in E. Coli.

Isotype: IgG2b

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-KCNQ1 (ABIN969227)

Jiang, Xu, Wang, Toyoda, Liu, Zhang, Robinson, Tseng: "Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2." dans: The Journal of biological chemistry, Vol. 284, Issue 24, pp. 16452-62, (2009) (PubMed).

Détails sur KCNQ1

Antigène: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Autre désignation: KCNQ1

Sujet: This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. 

Poids moléculaire: 95 kDa

ID gène: 3784

UniProt: P51787

Pathways: Negative Regulation of Hormone Secretion, Sensory Perception of Sound