MAP4K4 anticorps (AA 400-500)

N° du produit ABIN969274

Cet anticorps Souris Monoclonal détecte spécifiquement MAP4K4 dans ELISA. Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour MAP4K4 anticorps (AA 400-500) (ABIN969274)

Antigène: MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAP4K4 est non-conjugé

Application: ELISA

Clone: 4H9E7

Détail du produit anti-MAP4K4 anticorps

Épitope: AA 400-500

Fonction: MAP4K4 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-MAP4K4 (ABIN969274)

Bouzakri, Zierath: "MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance." dans: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7783-9, (2007) (PubMed).

Poinat, De Arcangelis, Sookhareea, Zhu, Hedgecock, Labouesse, Georges-Labouesse: "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans." dans: Current biology : CB, Vol. 12, Issue 8, pp. 622-31, (2002) (PubMed).

Becker, Huynh-Do, Holland, Pawson, Daniel, Skolnik: "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation." dans: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1537-45, (2000) (PubMed).

Détails sur MAP4K4

Antigène: MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))

Autre désignation: MAP4K4

Sujet: MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.

ID gène: 9448

UniProt: O95819