PARL anticorps (AA 112-167)

N° du produit ABIN969340

Cet anticorps Souris Monoclonal détecte spécifiquement PARL dans ELISA. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour PARL anticorps (AA 112-167) (ABIN969340)

Antigène: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PARL est non-conjugé

Application: ELISA

Clone: 8C4B2

Détail du produit anti-PARL anticorps

Épitope: AA 112-167

Fonction: PARL Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of PARL (aa112-167) expressed in E. Coli.

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-PARL (ABIN969340)

McQuibban, Saurya, Freeman: "Mitochondrial membrane remodelling regulated by a conserved rhomboid protease." dans: Nature, Vol. 423, Issue 6939, pp. 537-41, (2003) (PubMed).

Pellegrini, Passer, Canelles, Lefterov, Ganjei, Fowlkes, Koonin, DAdamio: "PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2." dans: Journal of Alzheimer's disease : JAD, Vol. 3, Issue 2, pp. 181-190, (2002) (PubMed).

Détails sur PARL

Antigène: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Autre désignation: PARL

Sujet: PARL: presenilin associated, rhomboid-like. This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.

ID gène: 55486

UniProt: Q9H300

Pathways: Autophagy