PARL anticorps (AA 112-167)

N° du produit ABIN969340

Détail du produit anti-PARL anticorps

Antigène: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Épitope: AA 112-167

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PARL est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogène: Purified recombinant fragment of PARL (aa112-167) expressed in E. coli.

Clone: 8C4B2

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-PARL (ABIN969340)

McQuibban, Saurya, Freeman: "Mitochondrial membrane remodelling regulated by a conserved rhomboid protease." dans: Nature, Vol. 423, Issue 6939, pp. 537-41, (2003) (PubMed).

Pellegrini, Passer, Canelles, Lefterov, Ganjei, Fowlkes, Koonin, DAdamio: "PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2." dans: Journal of Alzheimer's disease : JAD, Vol. 3, Issue 2, pp. 181-190, (2002) (PubMed).

Détails sur PARL

Antigène: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Autre désignation: PARL (PARL Produits)

Synonymes: anticorps PSARL, anticorps PSARL1, anticorps PSENIP2, anticorps RHBDS1, anticorps D16Ertd607e, anticorps PRO2207, anticorps Psarl, anticorps parl, anticorps zgc:112986, anticorps presenilin associated rhomboid like, anticorps presenilin associated, rhomboid-like, anticorps presenilin associated, rhomboid-like a, anticorps PARL, anticorps Parl, anticorps parla

Sujet:

Description: PARL: presenilin associated, rhomboid-like. This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.

Aliases: PSARL, PSARL1, RHBDS1

ID gène: 55486

HGNC: 55486

Pathways: Autophagy