PROZ anticorps

N° du produit ABIN969368

L’anticorps Souris Monoclonal anti-PROZ a été validé pour WB et ELISA. Il convient pour détecter PROZ dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour PROZ anticorps (ABIN969368)

Antigène: PROZ (Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PROZ est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 2B4

Détail du produit anti-PROZ anticorps

Fonction: PROZ Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of PROZ expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-PROZ (ABIN969368)

Blyth, Favaloro, Harris, Kairaitis: "Protein Z is reduced in chronic kidney disease and not elevated in patients on haemodialysis." dans: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Vol. 19, Issue 1, pp. 23-5, (2008) (PubMed).

Paidas, Ku, Lee, Manish, Thurston, Lockwood, Arkel: "Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications." dans: Journal of thrombosis and haemostasis : JTH, Vol. 3, Issue 3, pp. 497-501, (2005) (PubMed).

Détails sur PROZ

Antigène: PROZ (Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ))

Autre désignation: PROZ

Sujet: PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency, there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.

Poids moléculaire: 45 kDa

ID gène: 8858

UniProt: P22891