PSIP1 anticorps

N° du produit ABIN969370

Cet anticorps Souris Monoclonal détecte spécifiquement PSIP1 dans WB, IHC, ELISA et ICC. Il présente une réactivité envers Humain, Rat et Singe et a été mentionné dans 1 publication.

Aperçu rapide pour PSIP1 anticorps (ABIN969370)

Antigène: PSIP1 (PC4 and SFRS1 Interacting Protein 1 (PSIP1))

Reactivité: Humain, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PSIP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Clone: 6E4

Détail du produit anti-PSIP1 anticorps

Fonction: PSIP1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human PSIP1 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-PSIP1 (ABIN969370)

Shun, Botbol, Li, Di Nunzio, Daigle, Yan, Lieberman, Lavigne, Engelman: "Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity." dans: Journal of virology, Vol. 82, Issue 23, pp. 11555-67, (2008) (PubMed).

Détails sur PSIP1

Antigène: PSIP1 (PC4 and SFRS1 Interacting Protein 1 (PSIP1))

Autre désignation: PSIP1

Sujet: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.

Poids moléculaire: 75 kDa

ID gène: 11168

UniProt: O75475

Pathways: Chromatin Binding, Ribonucleoprotein Complex Subunit Organization