SNAIL anticorps

N° du produit ABIN969409

Cet anticorps Souris Monoclonal détecte spécifiquement SNAIL dans ELISA. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour SNAIL anticorps (ABIN969409)

Antigène: SNAIL (SNAI1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SNAIL est non-conjugé

Application: ELISA

Clone: 6D2

Détail du produit anti-SNAIL anticorps

Fonction: SNAI1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human SNAI1 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-SNAIL (ABIN969409)

Wanami, Chen, Peiró, García de Herreros, Bachelder: "Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression." dans: Experimental cell research, Vol. 314, Issue 13, pp. 2448-53, (2008) (PubMed).

Herranz, Pasini, Díaz, Francí, Gutierrez, Dave, Escrivà, Hernandez-Muñoz, Di Croce, Helin, García de Herreros, Peiró: "Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor." dans: Molecular and cellular biology, Vol. 28, Issue 15, pp. 4772-81, (2008) (PubMed).

Détails sur SNAIL

Antigène: SNAIL (SNAI1)

Autre désignation: SNAI1

Sujet: Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.

Poids moléculaire: 29 kDa

ID gène: 6615

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling